"The best way to get the right answer on the internet is not to ask a question; it's to post the wrong answer." - Cunningham's Law
This pertains to 2012 SARS coronavirus vaccines. Without context, and as it's now 2021, this appears to most likely be quite irrelevant. I'll assume
you meant well though. 
Quote: Originally posted by gnukid  |
Coronavirus (COVID-19) Update: June 25, 2021
https://www.fda.gov/news-events/press-announcements/coronavi...
"Today, the FDA is announcing revisions to the patient and provider fact sheets for the Moderna and Pfizer-BioNTech COVID-19 vaccines regarding the
suggested increased risks of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the tissue surrounding the heart)
following vaccination."
|
CDC says:
- "Most patients who received care responded well to treatment and rest and quickly felt better."
- "Patients can usually return to their normal daily activities after their symptoms improve. They should speak with their doctor about return to
exercise or sports."
- "CDC continues to recommend COVID-19 vaccination for everyone 12 years of age and older, given the risk of COVID-19 illness and related, possibly
severe complications."
- "Getting vaccinated is the best way to help protect yourself and your family from COVID-19."
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/my...
CNBC reports:
----
“The risk of myocarditis and pericarditis appears to be very low given the number of vaccine doses that have been administered,” Janet Woodc-ck,
acting FDA commissioner, said in a statement.
“The benefits of Covid-19 vaccination continue to outweigh the risks, given the risk of Covid-19 diseases and related, potentially severe,
complications,” she said.
The FDA update follows a review and discussion by the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices
meeting on Wednesday.
There have been more than 1,200 cases of a myocarditis or pericarditis mostly in people 30 and under who received the shots, according to presentation
slides from the CDC meeting.
About 300 million shots had been administered as of June 11, according to the CDC. There have been just 12.6 heart inflammation cases per million
doses for both vaccines combined.
https://www.cnbc.com/2021/06/26/fda-adds-warning-of-rare-hea...
https://www.cnbc.com/2021/06/23/cdc-reports-more-than-1200-c...
----
"12.6 heart inflammation cases per million doses for both vaccines combined."
"The benefits of Covid-19 vaccination continue to outweigh the risks, given the risk of Covid-19 diseases and related, potentially severe,
complications" - Janet Woodc-ck, acting FDA Commissioner
The following is from Derek Lowe in Feb 2021, four months after the article above was published (and C-19 vaccines had significantly rolled out
further):
- "The SARS experience taught us a lot of extremely useful lessons, as it turned out. SARS-Cov-2 is rather closely related to the 2003 SARS
coronavirus, and if you're going to have a worldwide pandemic, you're far better off with one that's so much like something you've already poured
R|&|D investments into! In this case, the two big take-homes were that coronavirus vaccines could indeed suffer from ADE, and that this seemed to
depend on which protein you chose to base your vaccine around. Specifically, it was the vaccines that targeted the N (nucleoprotein) antigen of the
coronavirus that had ADE problems. That experience was thoroughly taken to heart in the vaccine developments of the last year: no one, to the best of
my knowledge, even bothered to target the SARS-Cov-2 N protein at all, for just this reason.
- "So now the Moderna and Pfizer/BioNTech vaccines have been rolled out in many parts of the world, along with the AstraZeneca/Oxford, Gamaleya, and
CanSino adenovirus vector vaccines. Those look to be joined soon by J&J's adenovirus vector and Novavax's recombinant protein subunit vaccines,
and likely more after that. So here's the key question: did any of these show ADE hints during their development? And are any of them showing signs of
it now? The short answers: they did not. And they are not.; ...and what I'm seeing is not one single case of ADE for any of them. Indeed, as mentioned
above, if something like that had shown up, it would have immediately released a bucket of clin-dev and regulatory sand into the gears of the whole
project."
- "Remember, the bad thing about antibody-dependent enhancement is that it leads to more severe disease when you're exposed again to the pathogen (or
when you're exposed after being vaccinated for it). And we're just not seeing that. At all. We are, and I am very, very happy to be able to say this,
seeing exactly the reverse. Watching the real-world data will alert us to any of the potential mechanisms (antibodies, T-cell effects, etc.) and
nothing is showing up."
- "No sign of ADE during the preclinical animal studies. No sign during the human clinical trials. No sign during the initial vaccine rollouts into
the population. And (so far) no sign of ADE even with the variant strains in different parts of the world. We have things to worry about in this
pandemic, but as far as I can tell today, antibody-dependent enhancement does not seem to be one of them. I understand why people would worry about
it, and want to avoid it. But if you're coming across reports that say that it's a real problem right now and that you should avoid getting vaccinated
because of it, well, I just don't see it. Some of that is well-intentioned caution, and some of it is probably flat-out anti-vaccine scaremongering."
https://www.science.org/content/blog-post/antibody-dependent...
https://en.wikipedia.org/wiki/Derek_Lowe
Also...
----
Why ADE Hasn't Been a Problem With COVID Vaccines
— Even with new variants, it's unlikely antibody-dependent enhancement will be an issue
by Veronica Hackethal, MD, MSc
March 16, 2021
- "Early in the pandemic, scientists engaged in a flurry of discussions about the best way to construct COVID-19 vaccines to ensure their efficacy and
safety. Some of these discussions centered around antibody-dependent enhancement of immunity (ADE), a potentially deadly immune phenomenon seen with
other viral infections and vaccines. So far, there have been no reports of ADE with COVID-19 vaccines."
- "Scientists say that ADE is pretty much a non-issue with COVID-19 vaccines"
- "Despite hesitancy about the relative newness of mRNA and adenoviral vector vaccines, these vaccines, in fact, have better safety profiles in terms
of ADE than older types of vaccines"
- "The bottom line is that not only is the new technology faster to respond to a new viral pandemic, but so much safer and much more clearly
scientifically designed"
https://www.medpagetoday.com/special-reports/exclusives/9164...
----
fwiw... Media Bias Fact Check website says medpage.com rates "very high" for factual reporting:
https://mediabiasfactcheck.com/medpage-today/
I assume this is well-intentioned caution for posting here. Thank you. 
This appears to only be info on how ACE2 is a means of recognizing the virus, not a health warning for those of us not in the biomed industry, etc.
I'm sure this was well-intentioned too. Thank you again.
Thank you for the information on ADE, ACE2, myocarditis, pericarditis, and the 2012 concerns on pulmonary immunopathology from SARS vaccines at the
time. Seems like much of this may be of little to no immediate concern for those with interests for info along the Baja California peninsula at this
time. I appreciate you limiting any further info on those topics addressed to new news from this date forward. Your kind understanding and cooperation
is greatly appreciated!!
[Edited on 9-7-2021 by BajaNomad] |
