BajaNomad

Chloroquine and hydroxychloroquine offer no help with COVID-19, large-scale study finds

Alm - 5-22-2020 at 01:48 PM

https://www.sciencedaily.com/releases/2020/05/200522113712.h...

"This is the first large scale study to find statistically robust evidence that treatment with chloroquine or hydroxychloroquine does not benefit patients with COVID-19. Instead, our findings suggest it may be associated with an increased risk of serious heart problems and increased risk of death. Randomised clinical trials are essential to confirm any harms or benefits associated with these agents. In the meantime, we suggest these drugs should not be used as treatments for COVID-19 outside of clinical trials."

BajaNaranja - 5-22-2020 at 02:52 PM

Four studies cited by this Reuters article support the contention that HCQ isn't panning out as a COVID-19 treatment:

https://www.reuters.com/article/us-health-coronavirus-usa-hy...

BajaNaranja - 5-22-2020 at 03:53 PM

Right, Bob and Susan, thanks for reading.

The Reuters article also says:

"An observational study of patients in France found that the drug [hydroxychloroquine] did not significantly reduce admission to intensive care or death in patients hospitalized with COVID-19 pneumonia who required oxygen."

Which is very much in agreement with the study that Alm shared. A succinct quote from that one:

"...treatment with the antimalarial drug chloroquine or its analogue hydroxychloroquine ... offers no benefit for patients with COVID-19."

Face the FACT !

MrBillM - 5-22-2020 at 04:33 PM

The Faithful are onboard ALL the way.

Once DT takes a position, there is NOTHING that can sway them away.

Trying isn't worth the bother.

If DT were to endorse intravenous injections of Canine urine, they'd be out trying to catch Fido's stream.

BTW-since the standard for treatment seems to be "Why Not ? What have you got to lose ?", WHY are we ignoring that cure-all proven by centuries of Jewish mothers ....................... Chicken Soup !

Cheaper and more readily available without prescription.

It "might" work.

SFandH - 5-22-2020 at 04:44 PM

Heard on NPR that lupus sufferers, who take chloroquine as a treatment are having a hard time getting it. Bozo has caused a supply shortage.

Bruce R Leech - 5-22-2020 at 04:54 PM

fake news

SFandH - 5-22-2020 at 04:57 PM

Could be. But.....

"Health experts are warning hundreds of thousands of people, mostly women, could be in pain thanks to a shortage of hydroxychloroquine (HCQ), a medicine used to treat Lupus, but now touted (and increasingly discredited) as a treatment for COVID-19."

https://www.forbes.com/sites/andrewwight/2020/05/06/coronavi...

What makes you think it is fake news?

[Edited on 5-23-2020 by SFandH]

thebajarunner - 5-22-2020 at 06:56 PM

Geez Louise.
If you are really sick you will reach for anything
Remember when late term cancer patients went to Rosarito for laetrile (apricot pit) treatment?

Chloraquine warnings are clear for people with BP issues and other related problems. Got high blood pressure? Don't take it!

I took it for two years while traveling in malaria prone countries. I just looked in the mirror, still here!!

Quit because the protocol said it might "mask the symptoms" of malaria so I discontinued.

mtgoat666 - 5-22-2020 at 07:25 PM

Now that the weather and pool are warm, I have taken to nightly treatment with quinine in the form of gin and tonic. My form of quinine is far superior to that crappy synthetic quinine, hdrochloroquinine, that trump is choking down.

There is no evidence that my quinine treatment causes heart arythmia :light:

[Edited on 5-23-2020 by mtgoat666]

mtgoat666 - 5-22-2020 at 07:28 PM

Quote: Originally posted by Bob and Susan  
there is no shortage...in fact any pharmacy in texas has it with doctors note...

the forbes article uses data from the aspen institute a think tank in WashingtonDC...

their money comes from...
Bill Clinton, Hillary Clinton, Bill Gates, Eric Holder, Madeleine Albright, Sandra Day O'Connor, Ruth Bader Ginsburg, Salam Fayyad


What makes you believe every ridiculous conspiracy theory?

Got a brain? Use it!

AKgringo - 5-22-2020 at 08:04 PM

I have been taking medications for years now to treat an arrhythmia, and enlarged left ventricle. Since I am already taking the drugs to treat potential side effects of hydrochloroquinine, I should be good to go with the malaria pills!

Back away from the keyboard...I am just kidding! :biggrin:

LancairDriver - 5-22-2020 at 08:18 PM

Maybe we can get some more opinions from our favorite climate scientists.😁

SFandH - 5-23-2020 at 09:53 AM

Quote: Originally posted by Bob and Susan  
there is no shortage...in fact any pharmacy in texas has it with doctors note...

the forbes article uses data from the aspen institute a think tank in WashingtonDC...

their money comes from...
Bill Clinton, Hillary Clinton, Bill Gates, Eric Holder, Madeleine Albright, Sandra Day O'Connor, Ruth Bader Ginsburg, Salam Fayyad


Well, gee whiz, the information must be incorrect then. :lol:

I looked into it, the FDA website says there was a shortage of the drug but it has been remedied. The drug company has stepped up to the challenge.

caj13 - 5-23-2020 at 10:11 AM

Quote: Originally posted by Bob and Susan  
sciencedaily.com just reprints press releases...

the info came from Lancet

The Lancet is owned by Elsevier...Richard Horton
This publication has editorial offices in London, New York,
and Beijing CHINA

do you really think it hasn't been compromised

Richard Horton is paid by the WHO...and the WHO follows Chinas lead...

"On 1 May, Horton was interviewed for the Chinese news program Xinwen Lianbo and reportedly praised the 'innovation' of the Chinese response, while decrying politicians from other countries for making statements critical of the Chinese government."

[Edited on 5-22-2020 by Bob and Susan]


No Bob, I do not believe it has been compromized. You seem to have no idea how real science is conducted. how the results are analyzed, How the study is reviewed, and vetted before publication. The whole world is not involved in some gigantic get trump consporacy theory. sorry, you need to hold him accountable for his woreds and actions instead of tryiung to lay it off as some sort of world wide conspiracy!

but boy oh boy are those lefty libs getting good at hoaxes eh? their latest hoax has infected 5.5 million people world wide and killed 350,000, thats pretty good hoaxing - don't you think!

sorry to interrupt you, I assume you have a daily appointment for your solar enema - right!

SFandH - 5-23-2020 at 10:37 AM

Quote: Originally posted by Bob and Susan  
you mean people were turned away because there was no drug...

or was it there was not enough to give to every person in the world?

the reality is no person who needed it went without it


I don't think anybody had any plans to make it for "every person in the world". I'm surprised you consider that a possibility.

And it's not what I think. The Forbes article said:

"Health experts are warning hundreds of thousands of people, mostly women, could be in pain thanks to a shortage of hydroxychloroquine (HCQ), a medicine used to treat Lupus,"

Here is a link to the FDA website listing drug shortages:

https://www.accessdata.fda.gov/scripts/drugshortages/default...

It shows the chloroquine shortage as being resolved.

There was a shortage, there no longer is.

Your dismissal of information from the Aspen Institute, (founded in 1949) because you don't like some of the people you allege donate to it is just plain covfefe.


"The Aspen Institute is largely funded by foundations such as the Carnegie Corporation, the Rockefeller Brothers Fund, the Gates Foundation, the Lumina Foundation, and the Ford Foundation,"

https://en.wikipedia.org/wiki/Aspen_Institute

[Edited on 5-23-2020 by SFandH]

SunDevil - 5-24-2020 at 06:31 AM

A quick online search for "Hydroxychloroquine Study" would turn up good news in our fight against Covid-19.

Don't let your politics infect every aspect of your life.

-

Drug Combo with Hydroxychloroquine Promising: NYU Study

Researchers at NYU's Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus.

https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-stu...

SFandH - 5-27-2020 at 05:15 PM

Funny:

https://www.youtube.com/watch?v=0dUUkpVpS_k

Feathers - 5-27-2020 at 06:40 PM

Quote: Originally posted by SunDevil  
A quick online search for "Hydroxychloroquine Study" would turn up good news in our fight against Covid-19.

Don't let your politics infect every aspect of your life.

-

Drug Combo with Hydroxychloroquine Promising: NYU Study

Researchers at NYU's Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus.

https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-stu...


You're asking far too much, SunDevil. The TDS herd mentality is fairly strong here... and they've got the biggest mouths. Previous replies say it all.



[Edited on 5-28-2020 by Feathers]

BajaNaranja - 5-27-2020 at 10:17 PM

https://www.politico.com/news/2020/05/27/fauci-hydroxychloro...
May 27, 2020

National Institute of Allergy and Infectious Diseases Director Anthony Fauci on Wednesday became the first Trump administration official to say definitively that hydroxychloroquine is not an effective treatment for the coronavirus, based on the available data.

"The scientific data is really quite evident now about the lack of efficacy," Fauci — the U.S. government's top infectious disease expert — said on CNN.

But he stopped short of calling for an outright ban of the drug, which President Trump said he was taking last week as a preventative measure after a top White House aide was diagnosed with the coronavirus.

Fauci's comments come days after the Lancet published a 96,000-patient observational study that concluded that hydroxychloroquine had no effect on Covid-19 and may have even caused some harm.

France decided this week to ban the use of hydroxychloroquine, even in clinical trials, and the WHO has paused its clinical trials of the drug.

There is no data yet from randomized, controlled clinical trials of hydroxychloroquine — the gold standard for evaluating potential treatments. But Fauci was unequivocal on Wednesday, saying that "the data are clear right now."

BajaNaranja - 5-27-2020 at 10:21 PM

This article is a bit older (April 8), but gives some background on why the current administration may be promoting hydroxychloroquine u$age:

https://www.opensecrets.org/news/2020/04/dark-money-groups-p...

‘Dark money’ groups pushed Trump to back unproven COVID-19 treatment

A conservative “dark money” group that received funding from the pharmaceutical industry’s largest trade organization pushed President Donald Trump to use unproven antimalarial drug hydroxychloroquine to treat COVID-19 and make it more widely available.

Last month, the conservative nonprofit group Job Creators Network collaborated with health care nonprofit Physicians for Reform to launch an online petition, a series of Facebook ads and a mass text message campaign urging Trump to make hydroxychloroquine available to treat patients battling COVID-19, Sludge reported. These groups do not disclose their sources of funding.

“There is clear and ever-mounting evidence that the anti-malaria drug hydroxychloroquine can significantly help patients who contract coronavirus,” the petition read.

One of Trump’s most influential supporters, Home Depot co-founder Bernard Marcus, founded the Job Creators Network in 2011. Marcus gave $7 million to outside groups supporting Trump’s 2016 presidential run. He also gave $100,000 to the pro-Trump super PAC America First Action in 2018 to further support Trump’s second presidential bid and plans to spend even more to support Trump’s reelection.

Physicians for Reform often works with conservative advocacy group Freedomworks to influence the deregulation of health care policies.

Pharmaceutical Research and Manufacturers of America gave millions in grants to conservative groups in 2018 that pushed industry-friendly policies to Trump, according to tax returns analyzed by OpenSecrets. The industry’s top lobbying group gave FreedomWorks $100,000 in 2018. It also gave $500,000 to the Job Creators Network in 2017.

PhRMA represents the most powerful drug companies in the country such as Bayer, Novartis and Teva. These companies, along with Mylan, have pledged to donate 200 million hydroxychloroquine tablets for clinical testing, according to Job Creators Network’s petition. These pharmaceuticals stand to profit the most if the drug is officially used to treat COVID-19.

Sandoz, a division of Novartis, donated 30 million doses of hydroxychloroquine sulfate to the Department of Health and Human Services. Bayer also donated one million doses of medical grade chloroquine phosphate to the Strategic National Stockpile last month.

PhRMA spent a record $29.3 million on lobbying in 2019. It hired 183 lobbyists to influence policy on its behalf. More than 70 percent of its lobbyists formerly held a position in government.

Infectious disease expert Dr. Anthony Fauci argued that hydroxychloroquine is unproven to combat COVID-19 and claims that the drug is successful are based on anecdotal evidence, Axios reported. Despite limited evidence on the drugs’ effectiveness in COVID-19 treatment, Trump has repeatedly promoted the use of the drug in the White House’s coronavirus briefings. Some doctors prescribing hydroxychloroquine in combination with other medications are seeing positive results in patients’ health.

There is a shortage of hydroxychloroquine, which is currently approved by the Food and Drug Administration to treat malaria, arthritis and lupus, a chronic autoimmune disease. The shortage is driven in part by doctors hoarding it and prescribing it to themselves, families and friends, ProPublica reported. Now, lupus patients are struggling to fill their prescriptions.

After Trump endorsed the drug for COVID-19 therapy, a couple in Arizona ingested chloroquine phosphate, which is not the medical form of chloroquine and is used as a parasite treatment for fish. The woman was hospitalized in critical care while her husband died, according to NBC News.

SunDevil - 5-31-2020 at 06:55 AM

Three studies find that hydroxychloroquine reduces chances of contracting Covid

New Delhi: The Indian Council of Medical Research (ICMR), the country’s apex body in the field, has found that consuming the drug hydroxychloroquine reduces the chances of getting infected with Covid-19.

As a result, ICMR released an advisory Friday to expand the usage of HCQ — an anti-malarial drug — as a preventive treatment against the novel coronavirus.

The conclusion has been drawn on the basis of three studies conducted by the ICMR.

The advisory suggests surveillance workers, paramilitary and police personnel, as well as medical staff working in non-Covid hospitals and blocks to start consuming the pill as “preventive therapy”.

https://theprint.in/health/hcq-breakthrough-icmr-finds-its-e...

UPDATE......Retraction!

AKgringo - 6-5-2020 at 07:00 AM

Here is today's update of the article that started this post; https://www.sciencedaily.com/releases/2020/05/200522113712.h...

Here is a Wall Street Journal link; https://www.msn.com/en-us/news/us/authors-retract-studies-th...

[Edited on 6-5-2020 by AKgringo]

BajaTed - 6-5-2020 at 07:08 AM

Reward vs risk

The team also found that serious cardiac arrhythmias, which cause the lower chamber of the heart to beat rapidly and irregularly, were more common in the groups receiving either of the four treatment regimens.

SunDevil - 6-5-2020 at 07:48 AM

You might wonder if there is a hidden reason why a cheap generic drug that only costs a few cents gets such bad press. Ideas anyone?

motoged - 6-5-2020 at 07:55 AM

No conspiracy..... just the facts . :light:

SFandH - 6-5-2020 at 08:19 AM

June 1st - National Center for Biotechnology Information, a branch of the National Institutes of Health:

"Oral hydroxychloroquine was authorized for emergency use by the US Food and Drug Administration (FDA) on March 28, 2020, to treat adult and adolescent patients who weigh 50 kg or more hospitalized with COVID‐19 for whom a clinical trial is not available, or participation is not feasible (https://www.fda.gov/media/136534/download). It was not approved for SARS‐CoV‐2 prevention. There are no scientifically established doses for SARS‐CoV‐2. Although pharmacometric modeling and simulation has been used by several groups to propose potential regimens, 3 , 4 , 5 these are targeted for hospitalized patients with advanced disease and no models have specifically evaluated regimens in the context of prophylaxis."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267462/

SFandH - 6-5-2020 at 08:31 AM

And, from The Lancet:

"The Indian Council of Medical Research, under the Ministry of Health and Family Welfare, has recommended chemoprophylaxis with hydroxychloroquine (400 mg twice on day 1, then 400 mg once a week thereafter) for asymptomatic health-care workers treating patients with suspected or confirmed COVID-19, and for asymptomatic household contacts of confirmed cases.2 The document states “its use in prophylaxis is derived from available evidence of benefit as treatment and supported by preclinical data”. Although some in-vitro evidence supports the antiviral activity of hydroxychloroquine and its precursor chloroquine, there is no peer-reviewed publication that evaluates either drug for exposure prophylaxis of SARS-CoV-2 infection. Even for treatment of diagnosed cases, only one small study reported faster nasopharyngeal viral clearance, with no data for clinical improvement.3 This evidence, or the lack thereof, hardly justifies state-endorsed, widespread use of hydroxychloroquine for prophylaxis."

https://www.thelancet.com/journals/laninf/article/PIIS1473-3...


SunDevil - 6-6-2020 at 08:25 AM

LANCET STUDY RETRACTION

The authors of the Lancet paper, 'Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: , have retracted their study.

They were unable to complete an independent audit of the data underpinning their analysis. As a result, they have concluded that they 'can no longer vouch for the veracity of the primary data sources.'

https://www.sciencedaily.com/releases/2020/05/200522113712.h...

The retraction happened a couple days ago and has not been widely reported.

SFandH - 6-6-2020 at 08:39 AM

SunDevil, there are two issues.

1. Does hydroxy prevent COVID-19

2. Does hydroxy provide an effective treatment for patients with COVID-19.

The Lancet retraction had to do with a study for the second issue. They retracted the study not because of their conclusion that it is not an effective treatment was wrong but because they could not authenticate the veracity of the data they based their conclusion upon.

In fact, what it is beginning to look like is that hydroxy is useful as a treatment but its efficacy as a preventative is still undecided.

The FDA has approved it for treatment but not for prevention....yet.

SunDevil - 6-6-2020 at 09:42 AM

We should all try and keep an open mind, especially about things we are not familiar with.

Insults and vulgar language in someone's posts is a sign that they are the kind of person that Jeff Foxworthy jokes about.

Anyone wanting to learn more about the controversy around the retracted Lancet study can do their own research. Search online for something like 'why was lancet covid study retracted' and you might stumble across the Guardian article below. The Guardian is a UK publication with a left-of-center perspective and they have no love for anything Trump.

https://www.theguardian.com/world/2020/jun/04/covid-19-lance...

Nobody reputable has claimed the drug in question is a vaccine.

BajaNaranja - 6-17-2020 at 03:46 PM

Looks like hydroxychloroquine will be on sale, red hat wearing believers should stock up.

"The US now has 66 million surplus anti-malaria pills after the FDA revoked an emergency waiver allowing chloroquine and hydroxychloroquine"

https://www.businessinsider.com/hydroxychloroquine-us-surplu...

The US now has 66 million excess anti-malaria pills after the FDA U-turned on chloroquine and hydroxychloroquine.

The FDA said the drugs were likely ineffective in treating COVID-19, and could be dangerous. It previously allowed the drugs to be used in hospitalized coronavirus patients.

The government has sent out 31 million hydroxychloroquine tablets to state agencies, The New York Times reported, and now has 63 million left over, alongside 3 million chloroquine pills.

Officials are now trying to figure out what to do with the excess drugs, and are working to "determine to available options," the Department of Health and Human Services said.

Dr. Rick Bright, the former head of the US Biomedical Advanced Research and Development Authority (BARDA), said they "should be destroyed."

mtgoat666 - 6-17-2020 at 05:00 PM

Quote: Originally posted by BajaNaranja  
Looks like hydroxychloroquine will be on sale, red hat wearing believers should stock up.

"The US now has 66 million surplus anti-malaria pills after the FDA revoked an emergency waiver allowing chloroquine and hydroxychloroquine"

https://www.businessinsider.com/hydroxychloroquine-us-surplu...

The US now has 66 million excess anti-malaria pills after the FDA U-turned on chloroquine and hydroxychloroquine.

The FDA said the drugs were likely ineffective in treating COVID-19, and could be dangerous. It previously allowed the drugs to be used in hospitalized coronavirus patients.

The government has sent out 31 million hydroxychloroquine tablets to state agencies, The New York Times reported, and now has 63 million left over, alongside 3 million chloroquine pills.

Officials are now trying to figure out what to do with the excess drugs, and are working to "determine to available options," the Department of Health and Human Services said.

Dr. Rick Bright, the former head of the US Biomedical Advanced Research and Development Authority (BARDA), said they "should be destroyed."


those malaria pills will be useful, after global warming introduces all the tropical mosquitoes into usa

SFandH - 6-17-2020 at 05:10 PM
Quote: Originally posted by BajaNaranja  
"The US now has 66 million surplus anti-malaria pills after the FDA revoked an emergency waiver allowing chloroquine and hydroxychloroquine"


Dr. Rick Bright, the former head of the US Biomedical Advanced Research and Development Authority (BARDA), said they "should be destroyed."


Hey!! Dr. Rick, consider this.

Malaria occurs in more than 100 countries and territories. About half of the world's population is at risk. Large areas of Africa and South Asia and parts of Central and South America, the Caribbean, Southeast Asia, the Middle East, and Oceania are considered areas where malaria transmission occurs.

https://www.cdc.gov/malaria/about/faqs.html



[Edited on 6-18-2020 by SFandH]